ABSTRACT
Although radiation and surgery are generally regarded as effective for treatment of prostate cancer (PCa) in majority of men, diagnosis and prognosis remains poor in patients with progressive disease. Disease –specific metabolites represent the effective end points with considerable ability to identify men at increased risk of disease progression. In the current study, serum levels of Sarcosine, free and total testosterone (fTesto and tTesto) were assayed to evaluate the tumorigenic properties of PCa in our locality. In this study, 150 prostate cancer, 200 benign prostatic hyperplasia (BPH) Patients diagnosed and 200 volunteer matched controls were evaluated. Serum sarcosine were 64.94±0.81 nmol/dl, 118.70±1.80 nmol/dl and 134.13±2.21 nmol/dl in PCa, BPH patients and controls respectively. Serum tTesto and fTesto levels were 5.09±0.15 ng/ml, 5.12±0.11 ng/ml and 13.42±0.26 pg/ml, 5.72±0.20 ng/ml, 13.93±0.24 ng/ml and 11.73±0.47 pg/ml in PCa, BPH patients and controls respectively. Values differ significantly (p˂0.05) between PCa, BPH patients and controls in all the analytes. Attempt was also made to define the reference ranges of these analytes in various age groups of the controls. We recommend the inclusion of Serum levels of Sarcosine, tTesto and fTesto into multiplex biomarker panel for PCa and BPH detection in our localities.
ABSTRACT
Aims: To examine the effects of micronutrient supplementation on CD4+ cell count and anthropometric parameters in 210 HIV-positive adult patients on highly active antiretroviral therapy and treatment naïve. Study Design: A prospective and interventional study was performed comparing five groups receiving daily either a micronutrients (Centrum) supplement or no supplement for 12 months, and the effects of micronutrients supplementation on CD4+ cell count and anthropometric parameters from baseline to 12 months were assessed. Place and Duration of Study: Antiretroviral Therapy Clinic, Usmanu Danfodiyo University Teaching Hospital, Sokoto and Department of Chemical Pathology and Immunology, Usmanu Danfodiyo University, Sokoto, between April, 2013 and September, 2014.